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Published Papers using Quasi Vivo

Publications featuring Quasi Vivo®.


  1. Meldrum, K., Amaral Duarte De Moura, J., Doak, S., & Clift, M. (2022). Dynamic Fluid Flow Exacerbates the (Pro-)Inflammatory Effects of Aerosolised Engineered Nanomaterials In Vitro. Nanomaterials12(19), 3431. https://doi.org/10.3390/nano12193431
  1. Spencer CE, Rumbelow S, Mellor S, Duckett CJ, Clench MR. Adaptation of the Kirkstall QV600 LLI Microfluidics System for the Study of Gastrointestinal Absorption by Mass Spectrometry Imaging and LC-MS/MS. Pharmaceutics. 2022; 14(2):364. https://doi.org/10.3390/pharmaceutics14020364
  1. Kupper N, Pritz E, Siwetz M, Guettler J, Huppertz B. Placental Villous Explant Culture 2.0: Flow Culture Allows Studies Closer to the In Vivo Situation. International Journal of Molecular Sciences. 2021; 22(14):7464. https://doi.org/10.3390/ijms22147464
  1. Geddes L, Themistou E, Burrows JF, Buchanan FJ, Carson L. Evaluation of the in vitro cytotoxicity and modulation of the inflammatory response by the bioresorbable polymers poly(D,L-lactide-co-glycolide) and poly(L-lactide-co-glycolide). Acta Biomater. 2021; 134:261-275. doi: 1016/j.actbio.2021.07.049
  1. Azimi T, Loizidou M, Dwek MV. Cancer cells grown in 3D under fluid flow exhibit an aggressive phenotype and reduced responsiveness to the anti-cancer treatment doxorubicin. Sci Rep. 2020;10(1):12020. https://doi.org/10.1038/s41598-020-68999-9
  1. Elbakary B, Badhan RKS. A dynamic perfusion based blood-brain barrier model for cytotoxicity testing and drug permeation. Sci Rep. 2020 Mar 2;10(1):3788. https://doi.org/10.1038/s41598-020-60689-w
  1. Hyndman L, McKee S, Mottram NJ, Singh B, Webb SD and McGinty S. Mathematical modelling of fluid flow and solute transport to define operating parameters for in vitroperfusion cell culture systems. Interface Focus, 2020, 10(2). https://doi.org/10.1098/rsfs.2019.0045
  1. Keable A, O’Neill R, MacGregor Sharp M, Gatherer M, Yuen HM, Johnston DA, Weller RO, Carare RO. ApoE4 Astrocytes Secrete Basement Membranes Rich in Fibronectin and Poor in Laminin Compared to ApoE3 Astrocytes. Int J Mol Sci. 2020; 21(12):4371. https://doi.org/10.3390/ijms21124371
  1. Tomlinson L, Hyndman L, Firman JW, Bentley R, Kyffin JA, Webb SD, McGinty S, Sharma P. In vitroLiver Zonation of Primary Rat Hepatocytes. Front Bioeng Biotechnol. 2019; 7(17). https://doi.org/10.3389/fbioe.2019.00017
  1. Ahmed, S., Chauhan, V.M., Ghaemmaghami, A.M. et al.New generation of bioreactors that advance extracellular matrix modelling and tissue engineering. Biotechnol Lett 41, 1–25 (2019). https://doi.org/10.1007/s10529-018-2611-7
  1. Miranda-Azpiazu P, Panagiotou S, Jose G, Saha S. A novel dynamic multicellular co-culture system for studying individual blood-brain barrier cell types in brain diseases and cytotoxicity testing. Sci Rep. 2018, 8(1). https://doi.org/10.1038/s41598-018-26480-8
  1. Berger E, Magliaro C, Paczia N, Monzel AS, Antony P, Linster CL, Bolognin S, Ahluwalia A, Schamborn JC. Millifluidic culture improves human midbrain organoid vitality and differentiation. Lab Chip, 2018, 18, 3172-3183. https://doi.org/10.1039/C8LC00206A
  1. Buesch, Stefanie & Schroeder, Jenny & Bunger, Maureen & D’Souza, Theresa & Stosik, Magdalene. (2018). A Novel In Vitro Liver Cell Culture Flow System Allowing Long-Term Metabolism and Hepatotoxicity Studies. Applied In Vitro Toxicology. 4. https://doi.org/10.1089/aivt.2018.0009
  1. Chandorkar P, Posch W, Zaderer V et al.Fast-track development of an in vitro 3D lung/immune cell model to study Aspergillus Sci Rep 711644 (2017). https://doi.org/10.1038/s41598-017-11271-4
  1. Martin K, Yuan X, Stimac G, Bannerman K, Anderson J, Roy C, Glykofrydis F, Yin H and Davies J (2017). Symmetry-breaking in branching epithelia: cells on micro-patterns under flow challenge the hypothesis of positive feedback by a secreted autocrine inhibitor of motility. Journal of Anatomy, 230(6), 766-774. https://doi.org/10.1111/joa.12599
  1. Rashidi H, Alhaque S, Szkolnicka D, Flint O and Hay D (2016). Fluid shear stress modulation of hepatocyte-like cell function. Archives of Toxicology, 90(7), 1757-1761. https://doi.org/10.1007/s00204-016-1689-8
  1. Nithiananthan S, Crawford A, Knock J, Lambert D and Whawell S (2016). Physiological Fluid Flow Moderates Fibroblast Responses to TGF-β1. Journal of Cellular Biochemistry, 118(4), 878-890. https://doi.org/10.1002/jcb.25767
  1. Pedersen J, Shim Y, Hans V, Phillips M, Macdonald J, Walker G, Andersen M, Clewell H and Yoon M (2016). Fluid Dynamic Modeling to Support the Development of Flow-Based Hepatocyte Culture Systems for Metabolism Studies. Frontiers in Bioengineering and Biotechnology, 4, 72. https://doi.org/10.3389/fbioe.2016.00072
  1. Shannahan J, Fritz K, Raghavendra A, Podila R, Persaud I and Brown J (2016). Disease-Induced Disparities in Formation of the Nanoparticle-Biocorona and the Toxicological Consequences. Toxicological Sciences, 152(2), 406-416. https://doi.org/10.1093/toxsci/kfw097
  1. Faure M, Guibert E, Alves S, Pain B, Ramé C, Dupont J, Brillard J and Froment P (2016). The insulin sensitiser metformin regulates chicken Sertoli and germ cell populations. Reproduction, 151(5), 527-538. https://doi.org/10.1530/REP-15-0565
  1. Ramachandran S, Schirmer K, Münst B, Heinz S, Ghafoory S, Wölfl S, Simon-Keller K, Marx A, Øie C, Ebert M, Walles H, Braspenning J and Breitkopf-Heinlein K (2015). In Vitro Generation of Functional Liver Organoid-Like Structures Using Adult Human Cells. PLoS ONE, 10(10), e0139345. https://doi.org/10.1371/journal.pone.0139345
  2. Ucciferri N, Collnot EM, Gaiser BK, Tirella A, Stone V, Domenici C, Lehr CM, Ahluwalia A. In vitro toxicological screening of nanoparticles on primary human endothelial cells and the role of flow in modulating cell response. Nanotoxicology, 2014; 8(6):697-708. https://doi.org/10.3109/17435390.2013.831500
  1. Giusti, S., Sbrana, T., La Marca, M., Di Patria, V., Martinucci, V., Tirella, A., Domenici, C. and Ahluwalia, A. (2014). A novel dual-flow bioreactor simulates increased fluorescein permeability in epithelial tissue barriers. Biotechnology Journal, 9(9). 1002/biot.201400004
  1. Pagliari S, Tirella A, Ahluwalia A, Duim S, Goumans M, Aoyagi T and Forte G (2014). A multistep procedure to prepare pre-vascularized cardiac tissue constructs using adult stem sells, dynamic cell cultures, and porous scaffolds. Frontiers in Physiology, 5(June), 210. https://doi.org/10.3389/fphys.2014.00210
  1. Mattei G, Giusti S and Ahluwalia A (2014). Design Criteria for Generating Physiologically Relevant In Vitro Models in Bioreactors. Processes, 2(3), 548-569. https://doi.org/10.3390/pr2030548
  1. Iori, E., Vinci, B., Murphy, E., Marescotti, M., Avogaro, A. and Ahluwalia, A. (2012). Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia. PLoS ONE, 7(4). https://doi.org/10.1371/journal.pone.0034704
  1. Vinci B, Duret C, Klieber S, Gerbal-Chaloin S, Sa-Cunha A, Laporte S, Suc B, Maurel P, Ahluwalia A and Daujat-Chavanieu M (2011). Modular bioreactor for primary human hepatocyte culture: Medium flow stimulates expression and activity of detoxification genes. Biotechnology Journal, 6(5), 554-564. https://doi.org/10.1002/biot.201000326
  1. Vozzi F, Mazzei D, Vinci B, Vozzi G, Sbrana T, Ricotti L, Forgione N and Ahluwalia A (2011). A flexible bioreactor system for constructing in vitro tissue and organ models. Biotechnology and Bioengineering, 108(9), 2129-2140. ttps://doi.org/10.1002/bit.23164
  1. Vinci B, Murphy E, Iori E, Meduri F, Fattori S, Marescotti M, Castagna M, Avogaro A and Ahluwalia A (2011). An in vitro model of glucose and lipid metabolism in a multicompartmental bioreactor. Biotechnology Journal, 7(1), 117-126. https://doi.org/10.1002/biot.201100177
  1. Mazzei D, Guzzardi M, Giusti S, and Ahluwalia A (2010). A low shear stress modular bioreactor for connected cell culture under high flow rates. Biotechnology and Bioengineering, 106(1), 127–137. https://doi.org/10.1002/bit.22671

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