+ 44 (0) 1709 361 241 info@kirkstall.com

Session Chair: Dr Beate Rinner

What is your current role at the University of Graz?

I am an Assistant Professor at the Medical University of Graz and Head of the Core Facility for Alternative Biomodels and Preclinical Imaging.


What does your research entail? What have you published about recently?

Our research focus is the establishment and detailed characterisation of tumour cell lines, especially from rare, difficult to treat tumours like chordoma, sarcoma, glioblastoma and melanoma.  Our group succeeded in the establishment of a sacral chordoma cell line (PLOS ONE:https://www.ncbi.nlm.nih.gov/pubmed/22002331) and a clival chordoma cell line, with a non-tumourigenic lymphoblastoid cell line from the same patient (Scientifc Reports: https://www.ncbi.nlm.nih.gov/pubmed/?term=rinner+gellner).


What is your relationship with Kirkstall? When did it start, are you currently collaborating on anything?

First we met at the EUSAAT meeting in Austria 2015. We set up a 3D dynamic cell culture with the help of the Kirkstall system for our cell lines at the end of 2016. Our aim is to establish  3D tumour models with tumour cells and surrounding cells.


Harvey Clewell - ACTT 2017 Keynote Speaker
# Author Year Subject Chamber Types Chamber Setup Flow Rate (µL/min)
1 Mazzei et al 2010 Designing a modular bioreactor with low shear stress and high flow rates for hepatocyte culture QV500 2 chambers in series 180; 60 -1000
2 Vinci et al (A) 2011 Liver detoxification gene expression and activity under flow QV500 250 – 500
3 Vozzi et al 2011 In vitro tissue and organ modelling using connected bioreactors QV500 3 chambers in series (then connected to Laminar Flow Chamber housing HUVECs in 2nd experiment) 250
4 Vinci et al (B) 2011 Inter-organ crosstalk in a 3-way glucose and lipid metabolism model QV500 3-way connected culture in series: chamber (hepatocytes) > Laminar Flow Chamber (endothelial cells) > chamber (adipocytes) 250
5 Vozzi et al 2011 Diclofenac dose-response in hepatocytes cultured in Quasi Vivo QV500 4 chambers in series 100
6 Iori et al 2012 Glycaemic challenge in a 3-way glucose and lipid metabolism model QV500 3-way connected culture in series: chamber (hepatocytes) > Laminar Flow Chamber (endothelial cells) > chamber (adipocytes) 250
7 InLiveTox consortium 2012 Gut-liver-vascular in vitro model for assessing nanoparticle (NP) toxicity QV500, QV600 (liquid-liquid) Intestinal circuit: apical QV600 (intestinal epithelium). Blood circuit: basal QV600 > QV500 (endothelial cells) > QV500 (hepatocytes)
8 Harrington et al 2014 Multicellular 3D human upper airway model
9 Giusti et al 2014 Dual-flow intestinal barrier model QV600 (liquid-liquid) 1 chamber, 2 unidirectional fluidic circuits Apical = 200, basal = 100
10 Pagliari et al 2014 Generating a vascularised cardiac tissue construct with cardiomyocyte-like and endothelial-like cells, using a 3D scaffold and dynamic culture QV500 2 chambers in series 200
11 Mattei, Giusti & Ahluwalia 2014 Physiologically relevant in vitro bioreactor design: using computational fluid dynamics to compare milli- and micro-fluidic systems QV500 1 chamber 180
12 Ucciferri et al 2014 Toxicity of nanoparticles and the role of flow in endothelial cell response in vitro QV500 1 chamber 100
13 Crawford & Bardsley 2014 Chondrocyte differentiation and ECM production in flow culture 100 – 500
14 Saha & Miranda-Azpiazu et al 2015 Blood brain barrier model QV600 1 chamber (astrocytes at base, pericytes basal side of insert, endothelial cells apical side of insert) 40
15 Ramachandran et al 2015 Generation and long-term culture of 3D liver organoids using upcytes QV500 1 chamber
16 Faure et al 2016 Effect of metformin on chicken Sertoli and germ cells QV500 2 chambers in series 250
17 Rashidi et al 2016 Using fluid shear stress to improve hepatocyte-like cell function QV Serially connected chambers 100 & 200
18 Shannahan et al 2016 Influence of iron oxide biocorona (layer of biomolecules adsorbed to surface of nanoparticle) on endothelial cells under physiological conditions QV500 1 chamber 1000
19 Pedersen et al 2016 Evaluation of flow systems for hepatocyte culture QV900 1 chamber 500
20 Nithiananthan et al 2016 Fibroblast differentiation in response to flow QV500 6 chambers (6 in series or two lots of 3 in series?) 75 & 150
21 Martin et al 2017 Challenging the hypothesis that branching morphogenesis in kidney epithelia is caused by a secreted autocrine inhibitor of cell motility QV500 2 chambers in series 3000
22 Chandorkar et al 2017/18? Generating perfused 3D multi-cellular upper respiratory tract epithelium model, testing function by exposure to antigen QV600 (air-liquid) 2 chambers in series 150
23 Lewis et al ? Use of flow & 3D scaffolds in cell culture and hepatocyte response to cyclophosphamide QV500
24 Da-silva et al ? Using Quasi Vivo (2D fluidic monoculture) to assess compounds that have low intrinsic clearance QV900 150
25 Yoon et al ? Non-specific binding in Quasi Vivo system with different types of tubing QV900

Get in touch for more information or to book now.

Contact Us

Address: Kirkstall, Ltd York House,
Outgang Lane, York
North Yorkshire, YO19 5UP

Phone: + 44 (0) 1709 361 241

Business Hours: Monday to Friday 9:00am-5:00pm (UK Time)