Why Quasi Vivo®?

Quasi Vivo® is an advanced interconnected cell culture flow system, specifically designed to provide a solution to the major problems academic and industry researchers encounter when using conventional in vitro systems and in vivo research.

SIGNIFICANTLY IMPROVED HUMAN RELEVANCE

By introducing flow to the in vitro environment, Quasi Vivo® significantly increases the physiological relevance of your research, enabling you to generate more accurate models, greatly improving confidence in the validity of your results.

Significant benefits include:

Improved cell viability
Close control of multiple variables
Flexible and easy to use
Time and cost savings
Long term culture

ADAPTABILITY

The Quasi Vivo® system has different chambers available, each of these have been designed to meet the needs of specific applications.

Consists of three biocompatible chambers capable of air-liquid and liquid-liquid interface. Compatible with standard inserts and highly modular for increased flexibility of use.

VIEW QV1200

Consists of 6 chambers on a standard multi-well plate footprint and is made from a material with little to none non-specific binding.

VIEW QV900

Compatible with commercially available transwells and inserts, giving users the ability to culture cells at the air liquid interface and create liquid/liquid barrier models.

VIEW QV600

FLEXIBILITY

Kirkstall’s Quasi Vivo® building block system offers great flexibility when designing your experiments.

Chambers are connected by a dynamic flow of media, transported through the system in tubing attached to chambers.

Quasi Vivo® chambers can be linked in series, allowing for the setup of extensive co-culture models.

EASE OF USE

When it came to designing the Quasi Vivo® system, as well as delivering significant scientific benefits we’ve also ensured the system is very user friendly.

That’s why we’ve used luer locks to connect chambers to tubing, ensuring all seals are secure and liquid tight, whilst also being very easy to use.

OXYGEN CONCENTRATIONS

The Quasi Vivo® systems were designed to provide metabolically active cells with ideal oxygen concentrations.

Furthermore oxygen gradients within the chamber can be predicted using computer modelling software and adapted by using inserts to alter the depth of the chambers.

FLOW RATE & SHEAR STRESS

The flow rate of the media is easily adapted by changing the settings on your peristaltic pump to ensure that the media perfuses cells at the correct level.

The chamber geometry ensures low levels of shear stress are applied to cells within the chamber (similar to that of hepatocyte shear stress), whilst using relatively high flow rates as delivered by the pump.

Again your desired level of shear stress can be predicted using computer modelling software and adapted by using inserts to alter the depth of the chambers.

MEDIA COMPOSITION

The recirculating media reduces the need for frequent media changes by allowing the cells themselves to condition their own environment and maintain this for over several days.

This leads to reduced perturbation of the system, giving you your weekends back!

AND THERE’S MORE…

In addition to all of these benefits, Quasi Vivo also provides you with ultimate ease of use and flexibility:

Optimum scale for useful outputs
Compatible with most scaffolds and gels
Compatible with most standard inserts and transwells
Fits in standard incubator
Powered by standard peristaltic pump
Works with any cell type

QUASI VIVO® USERS

The Quasi Vivo® is used for a variety of applications in academic and pharmaceutical laboratories around the world

Professor Jamie Davies

(University of Edinburgh, UK)

Professor of Experimental Anatomy and leader of a laboratory in Centre for Integrative Physiology.

Dr Simon A. Whawell

(University of Sheffield, UK)

Reader in Oral Science & Director of Postgraduate Taught Courses. Academic Unit of Oral & Maxillofacial Pathology School of Clinical Dentistry

Dr Miriam Dwek

(University of Westminster, UK)

Reader in Biomedical Sciences, leader of the Cancer Research Group and Research Coordinator for the Department of Biomedical Sciences.

Quasi Vivo®, used in 100+ labs worldwide, getting started is easy and cost effective!

ENQUIRE NOW

Tissue-engineered microenvironment systems for modeling human vasculature

Authors: Anna Tourovskaia, Mark Fauver, Gregory Kramer, Sara Simonson and Thomas Neumann
Journal: Exp Biol Med (Maywood) 2014 239: 1264

VIEW PAPER

A High-Throughput Bioreactor System for Simulating Physiological Environments

Journal: Exp Biol Med (Maywood) 2014 239: 1096
Authors: David Pamies, Thomas Hartung and Helena T Hogberg

VIEW PAPER

Physiology and metabolism of tissue-engineered skeletal muscle

Journal: Exp Biol Med (Maywood) 2014 239: 1203
Authors: Cindy S Cheng, Brittany NJ Davis, Lauran Madden, Nenad Bursac and George A Truskey

VIEW PAPER

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Address: Kirkstall, Ltd York House,
Outgang Lane, York
North Yorkshire, YO19 5UP

Phone: + 44 (0) 1709 361 241

Business Hours: Monday to Friday 9:00am-5:00pm (UK Time)