An Organ On A Chip Technology
WHAT IS ORGAN ON A CHIP?
An organ on a chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems, a type of artificial organ.
It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.
WHO’S DOING IT?
Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy.
Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.
WHERE DOES QUASI VIVO® FIT?
There are currently many research groups currently developing Organ on a Chip technology, using microfluidics. Kirkstall’s Quasi Vivo® system could be described as being “millifuildic” due to it being designed using a standard 24-well plate size.
This size for protocols developed for static cultures to easily be transferred to the system, as well as providing compatibility with both coverslips and a range of 3D scaffolds and providing a range of benefits;
- Easier to predict and control the research environment.
- Better control of flow rates and shear stress.
- More material for end point assays
- Easier to manipulate
- Low pressures
- No complicated external control systems
- Fits within most consumables budgets.
Commercially available and used in 70+ labs worldwide, getting started is easy and cost effective
Address: Kirkstall, Ltd York House,
Outgang Lane, York
North Yorkshire, YO19 5UP
Phone: + 44 (0) 1709 361 241
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